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目的:研究14-3-3夼蛋白在人乳腺癌中的表达和预后的临床意义。方法:在210例人乳腺癌组织样本中,通过免疫组化的方法检测14-3-3夼蛋白的表达情况,并分析其表达与乳腺癌临床病理学特征间的相关性及与患者总生存期的关系。结果:在210乳腺癌组织中,14-3-3夼蛋白的阳性表达为64.3%。卡方检验分析表明,14-3-3夼蛋白的表达与患者的发病年龄、肿瘤大小、组织分化程度以及HER2状态均没有相关性(P>0.05);而14-3-3夼蛋白高表达与高TNM分期(P=0.013)、淋巴结转移(P<0.0001)以及ER阴性(P=0.006)存在相关性。Spearman相关性分析检测发现,14-3-3夼蛋白高表达与高TNM分期(r=-0.187,P=0.006)、阳性淋巴结转移(r=-2.272,P<0.0001)呈正相关,而与ER阳性状态(r=-0.046,P=0.003)呈负相关。Kaplan-Meier分析结果显示:伴有14-3-3夼蛋白高表达患者的DFS与OS明显少于14-3-3夼蛋白低表达的患者,log-rank检验提示P值分别为0.0379和0.0037,具有统计学意义。结论:在乳腺癌组织中,14-3-3夼作为癌基因表达增加,与乳腺癌的发展和转移发生呈正相关,14-3-3夼可以作为乳腺癌患者预后和疾病复发的检测指标。
Objective: To study the clinical significance of 14-3-3 夼 protein expression and prognosis in human breast cancer. Methods: The expression of 14-3-3 夼 protein was detected by immunohistochemistry in 210 specimens of human breast cancer. The correlation between the expression of 14-3-3 夼 protein and clinicopathological features of breast cancer was analyzed. Period of the relationship. RESULTS: In 210 breast cancer tissues, the positive expression of 14-3-3 夼 protein was 64.3%. Chi-square test analysis showed that there was no correlation between the expression of 14-3-3 夼 protein and the onset age, tumor size, histological differentiation and HER2 status (P> 0.05), while 14-3-3 夼 protein was highly expressed There was a correlation with high TNM stage (P = 0.013), lymph node metastasis (P <0.0001) and ER negative (P = 0.006). Spearman correlation analysis showed that high expression of 14-3-3 夼 protein was positively correlated with high TNM stage (r = -0.187, P = 0.006), positive lymph node metastasis (r = -2.272, P <0.0001) Positive status (r = -0.046, P = 0.003) was negatively correlated. Kaplan-Meier analysis showed that patients with high expression of 14-3-3 夼 protein had significantly lower DFS and OS than those with low expression of 14-3-3 夼 protein. Log-rank test suggested that P values were 0.0379 and 0.0037 ,has statistical significane. Conclusion: The expression of 14-3-3 夼 in breast cancer tissue is increased, which is positively correlated with the development and metastasis of breast cancer. 14-3-3 夼 can be used as a marker of prognosis and disease recurrence in breast cancer patients.