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目的探讨益智(AlpiniaoxyphyllaMiq)对小鼠实验性高脂血症的降血脂作用。方法实验分别用花生油和猪油造成高脂模型对照组(PE-HFD,LA-HFD),各组分别添加2%益智(AOM)和4%AOM。饲养观察28d后,用显色-比色法测定血清总胆固醇(TC)和血清高密度脂蛋白胆固醇(HDL-C),并计算出HDL-C/TC值和动脉硬化指数(AI)。结果实验中的自制高脂饲料可以成功地诱导小鼠产生高胆固醇血症及动脉硬化(P<0.01)。添加2%AOM组及添加4%AOM组的TC和AI均极显著低于HFD组(P<0.01),HDL-C/TC均极显著高于HFD组(P<0.01);添加2%AOM组的HDL-C显著高于HFD组(P<0.05);添加4%AOM组的HDL-C极显著高于HFD组(P<0.01)。且添加4%AOM的对上述4种指标的影响效果都优于2%AOM组的(P<0.01)。结论益智具有良好的预防和降低血脂作用。
Objective To investigate the hypolipidemic effect of Alpiniaoxyphylla Miq on experimental hyperlipidemia in mice. Methods Experiments were conducted using peanut oil and lard to produce a high-fat model control group (PE-HFD, LA-HFD). Each group was supplemented with 2% AOM and 4% AOM. After 28 days of observation, serum total cholesterol (TC) and serum high-density lipoprotein cholesterol (HDL-C) were measured by color-colorimetry, and HDL-C/TC values and arteriosclerosis index (AI) were calculated. Results The homemade high-fat diet in the experiment could successfully induce mice with hypercholesterolemia and arteriosclerosis (P<0.01). The TC and AI levels in the 2% AOM group and the 4% AOM group were significantly lower than those in the HFD group (P<0.01), and the HDL-C/TC levels were significantly higher than those in the HFD group (P<0.01); 2% AOM was added. The HDL-C in the group was significantly higher than that in the HFD group (P<0.05); the HDL-C in the 4% AOM group was significantly higher than that in the HFD group (P<0.01). And the effect of adding 4% AOM on the above four indexes was better than that of the 2% AOM group (P<0.01). Conclusion The puzzle has a good effect of preventing and reducing blood lipids.