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目的探讨传染性单核细胞增多症(IM)患儿外周血干扰素调节因子3(IRF-3)和EB病毒复制转录激活子(Rta)表达水平及其相关性。方法采用RT-PCR法检测IM患儿(A组,12例)和健康对照儿童(C组,12例)外周血IRF-3和Rta mRNA表达水平,分析A组IRF-3和Rta mRNA表达的相关性。结果 A组患儿外周血IRF-3mRNA表达水平低于C组,而Rta mRNA表达水平高于C组(P<0.01)。A组IRF-3与Rta mRNA表达呈负相关(r=-0.60,P<0.05)。结论 Rta mRNA可能参与EB病毒下调IM患儿IRF-3基因表达的过程。
Objective To investigate the expression and correlation of IRF-3 and Rta in children with infectious mononucleosis (IM). Methods The expression of IRF-3 and Rta mRNA in peripheral blood of IM infants (group A, n = 12) and healthy children (group C, n = 12) were detected by RT-PCR. Correlation. Results The expression of IRF-3 mRNA in peripheral blood of group A was lower than that of group C, while the expression of Rta mRNA was higher than that of group C (P <0.01). A group of IRF-3 and Rta mRNA expression was negatively correlated (r = -0.60, P <0.05). Conclusion Rta mRNA may be involved in the down-regulation of IRF-3 gene expression in children with IM.