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目的探讨绒毛蛋白(villin)在胃癌及癌前病变组织中的表达特点及其临床病理意义。方法应用免疫组织化学SP法,观察villin在20例正常胃粘膜、20例肠上皮化生、30例异型增生和60例胃癌组织中的表达情况。结果Villin在正常胃粘膜中无表达,在肠上皮化生、异型增生和胃癌组织中的表达阳性率分别为85.0%(17/20),66.7%(20/30)和48.3%(29/60);胃癌中villin的表达与肿瘤的大小、浸润及临床分期和淋巴结转移无关(P>0.05),而在高-中分化胃癌中较在低分化胃癌中表达明显增高(P<0.05)。结论Villin在胃粘膜癌变过程中表达下调,且与肿瘤的分化程度密切相关,是研究胃癌分化程度及预后的指标,可以作为肠上皮化生的标志物,对早期癌及重度异型增生的临床筛选具有重要意义。
Objective To investigate the expression of villin in gastric carcinoma and precancerous lesions and its clinicopathological significance. Methods Immunohistochemical SP method was used to observe the expression of villin in 20 cases of normal gastric mucosa, 20 cases of intestinal metaplasia, 30 cases of dysplasia and 60 cases of gastric carcinoma. Results The positive rate of Villin expression in normal gastric mucosa was not significantly higher than that in normal gastric mucosa (85.0% (17/20), 66.7% (20/30) and 48.3% (29/60), respectively) ). The expression of villin in gastric cancer was not related to tumor size, invasion, clinical stage and lymph node metastasis (P> 0.05), but was significantly higher in well-differentiated gastric cancer than in poorly differentiated gastric cancer (P <0.05). Conclusions The expression of Villin is down-regulated in the carcinogenesis of gastric mucosa and is closely related to the degree of differentiation of the tumor. It is an index to study the differentiation degree and prognosis of gastric carcinoma and can be used as a marker of intestinal metaplasia. The clinical screening of early carcinoma and severe dysplasia It is of great significance.