目的:观察姜黄醇提液对大鼠实验性胃溃疡的影响。方法:用乙酸涂抹法建立大鼠胃溃疡模型,IL-1β诱发溃疡复发模型,实验设正常对照组、模型组、假手术组、雷尼替丁组、姜黄醇提液组,在给药后第7、92天分别取大鼠胃标本采用免疫组化技术检测NF-κB表达的变化。结果:姜黄醇提液能使溃疡显著减轻,溃疡指数降低,并能下调NF-κB的表达。结论:姜黄醇提液具有抗溃疡及其复发的作用。 Objective: To observe the effect of turmeric alcohol extract on experimental gastric ulcer in rats. Methods: The model of gastric ulcer was established by acetic acid smear method and the ulcer recurrence model was induced by IL-1β. The normal control group, model group, sham operation group, ranitidine group and turmeric alcohol extract group were established. On the 7th and 92nd days, the changes of NF-κB expression were detected by immunohistochemistry in the rat stomach specimens respectively. Results: Turmeric alcohol extract can significantly reduce the ulcer, ulcer index decreased, and can down regulate the expression of NF-κB. Conclusion: The turmeric alcohol extract has the anti-ulcer and its recurrence effect.