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目的探讨术中超声造影及定量分析在诊断不同级别胶质瘤瘤体及瘤周水肿的临床应用价值。方法对病理证实为胶质瘤的60例患者行超声造影并用软件分析,分别获取胶质瘤瘤体及肿瘤周边感兴趣区的峰值强度、达峰时间、局部血容量、局部血流量及平均渡越时间,并对高、低级别胶质瘤瘤体和瘤周造影参数进行比较分析。结果 60例胶质瘤总体瘤体与瘤周水肿带的Peak%、TTP、RBV、RBF及MTT差异均有统计学意义。30例高、低级别胶质瘤瘤体与瘤体之间相比,Peak%、TTP、RBV、RBF及MTT差异均有统计学意义。30例高、低级别胶质瘤瘤周与瘤周水肿带之间相比,Peak%、TTP、RBV、RBF及MTT差异均有统计学意义。结论通过超声造影定量分析瘤体及瘤周水肿带获得的造影参数,可为脑胶质瘤的术中精确分级诊断提供有价值的信息。
Objective To investigate the clinical value of intraoperative contrast-enhanced ultrasound and quantitative analysis in the diagnosis of different grades of glioma and peritumorous edema. Methods Sixty patients with pathologically confirmed gliomas underwent contrast-enhanced ultrasound and software analysis to obtain the peak intensity, peak time, local blood volume, local blood flow and average volume The more time, and high and low grade glioma tumor and peritumoral contrast parameters were analyzed. Results There were significant differences in Peak%, TTP, RBV, RBF and MTT between 60 gliomas and peritumoral edema. The peak%, TTP, RBV, RBF and MTT in 30 cases of high and low grade gliomas were significantly different from those of the tumor. Peak%, TTP, RBV, RBF and MTT were significantly different between the high and low grade gliomas and the peritumoral edema zone. Conclusions Quantitative analysis of the contrast parameters obtained by contrast echocardiography in the tumor and peritumoral edema zone can provide valuable information for accurate intraoperative grading diagnosis of gliomas.