中央型桥脑髓鞘溶解(CentralPontineMyelinolysis,CPM)是桥脑基底中央髓鞘对称破坏,轴突和神经元完好而无血管病损和炎症征象所致的一组特殊病征,其主要表现为假性球麻痹,最后发展成完全或不完全的闭锁综合征。1　CPM的历史1949年Victor和Adams在波士顿C院会诊一个38岁病人表现 Central Pontine Myelinolysis (CPM) is a group of special symptoms caused by the symmetrical destruction of the central medullary pontine myelin sheath, the integrity of axons and neurons without vascular lesions and signs of inflammation. The main manifestations are: Paralysis, and finally developed into complete or incomplete atresia syndrome. 1 History of CPM Victor and Adams met a 38-year-old patient at Boston Common in 1949