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我院自９３年３月～１１月对正常８０例；肝硬化失代偿期２０例；肝硬化代偿期２０例；慢活肝２０；慢迁肝２０例，进行ＨＡ检测。本文对１６０例ＨＡ检测数值，用临床统计学方法，算出５组算术平均值、标准差、标准误、离差平方和。对５组进行ｔ检验，慢性肝病４组间有非常显著性差异（Ｐ＜０．００１）；ＨＡ值肝硬化失代偿期＞肝硬化代偿期＞慢活肝＞慢迁肝。证明慢性肝病纤维化程度越严重，ＨＡ水平越高。慢迁肝无纤维化与正常人组无显著性差异（Ｐ＞０．０５）。９９％观测数据的置信区间，计算出ＨＡ正常值范围为０～１１５．３３μｇ／Ｌ。并将１５０μｇ／Ｌ作为诊断肝硬化下限数值，用金标准对ＨＡ诊断肝硬化的特异度、灵敏度、精确度、阳性预告值、阴性预告值均为９０％，证明ＨＡ诊断肝硬化是特异性灵敏性、精确度高的生化指标之一，可取代血浆白蛋百Ａ／Ｇ比值及肝活检。另外对慢性肝病的鉴别诊断的慢性肝病进行ＨＡ动态观察，对肝纤维化程度和预后判断，更具有重要的临床意义。
In our hospital from March to November of the year, 80 cases were normal, 20 cases of decompensated liver cirrhosis, 20 cases of liver cirrhosis, 20 cases of slow-moving liver, and 20 cases of slow-moving liver. In this paper, 160 cases of HA detection values, using clinical statistics, to calculate the five groups of arithmetic mean, standard deviation, standard error, and the sum of squared deviations. The t-test was performed on 5 groups. There was a significant difference between the 4 groups of chronic liver disease (P<0.001); HA value decompensated liver cirrhosis stage> compensated liver cirrhosis stage> slow-moving liver> slow-moving liver. The more severe the degree of chronic liver fibrosis, the higher the HA level. There was no significant difference between the slow-moving liver fibrosis and the normal group (P>0.05). 99% of the observation data confidence interval, calculated HA normal range of 0 to 115.33μg/L. Using 150 μg/L as the lower limit of cirrhosis diagnosis, the specificity, sensitivity, accuracy, positive predictive value, and negative predictive value of HA in the diagnosis of cirrhosis with the gold standard were all 90%, demonstrating that HA is a specific and sensitive sensor for cirrhosis. One of the high-precision, high-accuracy biochemical indicators can replace the plasma albumin A/G ratio and liver biopsy. In addition, the dynamic observation of HA in the differential diagnosis of chronic liver disease, chronic liver disease, liver fibrosis and prognosis of the more important clinical significance.