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目的：探讨谷胱甘肽Ｓ－转移酶－π（Ｇｌｕｔａｔｈｉｏｎｅ－Ｓ－Ｔｒａｎｓｆｅｒａｓｅ π、ＧＳＴ－π、）在膀胱移行细胞癌的表达情况及临床意义。方法：采用免疫组化ＳＰ法，检测１０７例未经化疗的原发性膀胱移行细胞癌中ＧＳＴ－π、Ｐ糖蛋白（Ｐ－ｇｌｙｃｏｐｒｏｔｅｉｎ， Ｐｇｐ）表达情况。结果： ＧＳＴ－π染色分胞浆、胞核、胞浆与胞核共染三种情形，总阳性率为 ７２．９％；ＧＳＴ－π浆染色（单独胞浆、胞浆与胞核共染）阳性率为５８．９％，ＧＳＴ－π核染色（单独胞核、胞浆与胞核共染）阳性率为４６．７％，其中ＧＳＴ－π总体染色阳性和浆染色阳性与膀胱癌的病理分级、分期和术后腔内化疗复发有关，并与Ｐｇｐ表达密切相关；ＧＳＴ－π核染色阳性与膀胱癌的分级、术后腔内化疗复发无关，而与病理分期有关。结论：ＧＳＴ－π表达情况是预测原发性膀胱移行细胞癌腔内化疗疗效的有效标志物，ＧＳＴ－π浆染色较核染色更能预测膀胱癌的耐药性，ＧＳＴ－π核染色可能与膀胱癌进展有关。
Objective: To investigate the expression of Glutathione-S-Transferase π (GST-π) in bladder transitional cell carcinoma and its clinical significance. Methods: The expressions of GST-π and P-glycoprotein (Pgp) in 107 cases of primary bladder transitional cell carcinoma without chemotherapy were detected by immunohistochemical SP method. Results: The positive rate of GST-π staining in all three cases of cytoplasm, nucleus, cytoplasm and nucleus was 72.9%. GST-π staining (cytoplasm and cytoplasm alone) ) Positive rate was 58.9%. The positive rate of GST-π nuclear staining (co-staining of nuclei, cytoplasm and nucleus alone) was 46.7%, of which the positive staining of GST-π and positive staining of plasma were associated with bladder cancer Pathological grading, stage and postoperative recurrence of intracavitary chemotherapy related, and closely related to the expression of Pgp; GST-π nuclear staining positive and bladder cancer classification, postoperative recurrence of intracavitary chemotherapy has nothing to do, but with the pathological stage. Conclusion: The expression of GST-π is an effective marker for predicting the curative effect of endovascular chemotherapy in primary bladder transitional cell carcinoma. GST-π staining is more predictive of the drug resistance of bladder cancer than nuclear staining. The GST-π nuclear staining may be related to Bladder cancer progress related.