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汉防已甲素(下简称汉甲)和异搏定在离体兔、猪血小板聚集试验中,均能明显地抑制由花生四烯酸(AA)、二磷酸腺苷(ADP)和血小板活化因子(PAF)诱导的聚集反应,剂量与效应相关,汉甲的作用约2～10倍强于异搏定.在兔静脉注射汉甲10mg/kg或异搏定20mg/kg,也明显抑制AA、ADP和PAF诱导的血小板聚集反应.抑制作用在给药后20～30min开始,60min达到高峰,120min后作用逐渐消失.汉甲的作用机理可能与钙拮抗有关.
Han Fang A (hereinafter referred to Hanjia) and verapamil in isolated rabbit, pig platelet aggregation test, were significantly inhibited by arachidonic acid (AA), adenosine diphosphate (ADP) and platelet activation Factor (PAF) -induced aggregation reaction, dose and effect related to the role of Armor about 2 to 10 times stronger than verapamil intravenous injection of rabbits 10mg / kg verapamil or verapamil 20mg / kg, but also significantly inhibited the AA , Platelet aggregation reaction induced by ADP and PAF.The inhibitory effect started from 20 to 30 min after administration, reached the peak at 60 min, gradually disappeared after 120 min.The mechanism of action of Chinese hamster may be related to calcium antagonism.