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为确定脾在小鼠急性实验性肝损伤中的作用，采用配对设计Ｋａｒｂｅｒ氏法测定了假切脾和切脾小鼠Ｄ－氨基半乳糖的半数致死量，并作尸检和活检，假切脾组半数致死量为４８６８ｍｇ／ｋｇ体重，切脾组为４５９３ｍｇ／ｋｇ体重，两者之间行Ｕ检验，结果差异有显著性。提示脾参与了小鼠机体的抗急性肝损伤机制而具有保肝作用。
In order to determine the role of spleen in acute experimental liver injury in mice, the half-lethal dose of D-galactosamine in the spleen-spleen and spleen-spleen mice was determined by the paired design Karber’s method. The mice were sacrificed by autopsy and biopsy. The median lethal dose was 4868 mg / kg body weight, 4593 mg / kg body weight in the splenectomy group. The U test was performed between the two groups. The difference was significant. Prompt spleen involved in the mouse body anti-acute liver injury mechanism with hepatoprotective effect.