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目的分析心绞痛(AP)、急性心肌梗死(AMI)患者的病情变化与甲状腺功能变化情况,探讨AP、AMI的发生、发展与甲状腺功能变化的相关性。方法 60例AP患者作为AP组,60例AMI患者作为AMI组,60例正常对照者作为正常对照组,用真空采血管抽取研究对象静脉血,离心,分离血清,检测三组甲状腺相关指标[三碘甲腺原氨酸(T_3)、甲状腺素(T_4)、促甲状腺激素(TSH)]。结果 AP组和AMI组血清T_3[(0.89±0.22)、(0.61±0.19)pmol/L]、T_4浓度[(5.39±1.08)、(3.88±0.79)pmol/L]均低于正常对照组[(1.32±0.47)、(9.29±1.32)pmol/L](P<0.05),AP组与AMI组T_3、T_4浓度比较差异无统计学意义(P>0.05)。三组TSH浓度[(3.86±0.81)m IU/L VS(3.28±0.62)m IU/L VS(2.69±0.92)m IU/L]比较差异无统计学意义(P>0.05),但AMI组较AP组偏低。结论当发生AMI或AP时,患者血清T_3、T_4水平会降低,其下降越显著,则病情越重,TSH变化无显著性意义,表明血清T_3、T_4水平的变化是因心肌细胞缺血缺氧而继发或伴发的改变,是对心脏的一种保护性反应。
Objective To analyze the changes of the thyroid function and the changes of the patients with angina pectoris (AP) and acute myocardial infarction (AMI), and to explore the correlation between the occurrence and development of AP and AMI and thyroid function. Methods Sixty patients with AP were selected as AP group, 60 AMI patients as AMI group and 60 normal controls as normal control group. The venous blood was drawn by vacuum blood collection tube, centrifuged and serum was separated. Thyroid-related indicators [ Iodine thyronine (T_3), thyroxine (T_4), thyroid stimulating hormone (TSH)]. Results Compared with the normal control group, the levels of T_3 [(0.89 ± 0.22), (0.61 ± 0.19) pmol / L] and T_4 in the AP and AMI groups [(5.39 ± 1.08) and (3.88 ± 0.79) pmol / (1.32 ± 0.47) and (9.29 ± 1.32) pmol / L, respectively (P <0.05). There was no significant difference in the levels of T_3 and T_4 between AP and AMI (P> 0.05). There was no significant difference in TSH concentration between the three groups ([3.86 ± 0.81] m IU / L vs (3.28 ± 0.62) m IU / L vs (2.69 ± 0.92) m IU / L) Lower than the AP group. Conclusions Serum levels of T 3 and T 4 in patients with AMI or AP decrease when the AMI or AP occurs. The more significant the decline is, the more serious the disease is, and the change of TSH is of no significance. It indicates that the change of serum T 3 and T 4 levels is caused by myocardial ischemia and hypoxia And secondary or associated changes, is a protective reaction to the heart.