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生胃酮为一有效的治疗消化性溃疡药物。某些实验研究显示其主要作用于胃粘膜的增殖过程。从某些细胞动力学参数,已知慢性萎缩性胃炎的表现为以及有指数(LI)增加,再生时间缩短,细胞丧失率增加,和一特殊型的DNA分布模式。KIein等报告用生胃酮300mg/日治疗后可大大减少胃小凹颈区标记指数,使标记细胞仅限于颈区的增殖部分,并延长细胞更新时间。Domschke等测定胃冲洗液中DNA含量作为胃细胞丢失的指标,在胃溃疡病人用该药300mg/日治疗后,
Gastropin is an effective drug for the treatment of peptic ulcers. Some experimental studies have shown that it mainly acts on the proliferation of gastric mucosa. From certain cellular kinetic parameters, it is known that chronic atrophic gastritis manifests as increased index (LI), shortened regenerative time, increased cell loss, and a particular type of DNA distribution pattern. KIein et al. reported that treatment with 300 mg/day of carbenoxolone significantly reduced the labeling index of the gastric pit, making the labeled cells limited to the proliferative part of the neck and prolonging the cell renewal time. Domschke et al measured the DNA content in the gastric lavage fluid as an indicator of gastric cell loss. After gastric ulcer patients were treated with the drug 300 mg/day,