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对２２例正常人（Ａ组）、３０例高血压无左室肥大（ＬＶＨ）的病人（Ｂ组）及４０例高血压伴ＬＶＨ的病人（Ｃ组）的冠状动脉血流储备（ＣＦＲ）用经食道多普勒超声的方法进行了检查，以研究室性心律失常的发生与高血压伴ＬＶＨ及ＣＦＲ的可能关系。研究发现，与Ｂ组病人相比，Ｃ组病人ＣＦＲ显著降低，室性心律失常及复杂室性心律失常的发生率显著增高（分别为９０％，６０％比３０％，１０％，Ｐ＜０．０１）；Ｃ组病人中有ＣＦＲ降低者室性心律失常及复杂室性心律失常的发生率最高（９６．８％及６７．７％）．Ｃ组病人中无ＣＦＲ降低者，其室性心律失常及复杂室性心律失常之发生率与高血压无ＬＶＨ但有ＣＦＲ降低者相似（分别为６６．７％，２２．２％及６０％，２０％）。研究结果提示，在高血压病人ＬＶＨ及ＣＦＲ降低是室性心律失常发生的两个相加作用的危险因素。
Coronary flow reserve (CFR) was measured in 22 normal subjects (group A), 30 patients with hypertensive left ventricular hypertrophy (group B), and 40 patients with hypertensive LVH (group C) Transesophageal Doppler ultrasound was examined in order to study the possible occurrence of ventricular arrhythmias associated with hypertension with LVH and CFR. The study found that, compared with patients in group B, patients in group C had a significantly lower CFR, a significantly higher incidence of ventricular arrhythmias and complicated ventricular arrhythmias (90%, 60% vs. 30%, 10%, P <0 .01). The incidence of ventricular arrhythmias and complex ventricular arrhythmias was the highest in C group (96.8% vs 67.7%) with decreased CFR. Patients in group C who had no reduction in CFR had similar incidences of ventricular arrhythmias and complex ventricular arrhythmias to those with no LVH but no reduction in CFR (66.7%, 22.2%, and 60%, respectively) 20%). The results suggest that LVH and CFR reduction in hypertensive patients are risk factors for the two additive effects of ventricular arrhythmias.