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目的:探讨中药灌肠联合超声波治疗慢性盆腔炎对患者的临床疗效及细胞因子水平影响和复发情况。方法:120例慢性盆腔炎患者根据随机分组法分为研究组与对照组,各60例。两组患者均采用常规治疗。对照组采用超声波治疗,研究组在对照组基础上结合中药灌肠治疗。两组均以3个疗程评价疗效、细胞因子水平、安全性以及复发情况。结果:研究组总有效率(93.33%)显著高于对照组(76.67%),且有统计学差异(P<0.05);研究组血清TNF-α治疗后较治疗前显著减少(P<0.05),而IL-2、IL-10治疗后较治疗前显著增加(P<0.05);而对照组血清TNF-α、IL-2、IL-10治疗前后比较无统计学差异(P>0.05);研究组血清TNF-α治疗后显著低于对照组(P<0.05),而IL-2、IL-10治疗后显著高于对照组(P<0.05);两组在治疗期间均未见明显不良反应发生;研究组复发率显著低于对照组(P<0.05)。结论:中药灌肠联合超声波治疗慢性盆腔炎患者的临床疗效显著,可明显改善炎症反应,降低复发率,安全可靠,具有重要研究意义。
Objective: To investigate the effect of traditional Chinese medicine enema combined with ultrasonic treatment of chronic pelvic inflammatory disease on patients with clinical efficacy and cytokine levels and recurrence. Methods: One hundred and twenty patients with chronic pelvic inflammatory disease were divided into study group and control group according to randomization method, 60 cases each. Both groups were treated routinely. The control group with ultrasound treatment, the study group in the control group based on the traditional Chinese medicine enema treatment. Both groups evaluated efficacy, cytokine levels, safety and relapse with three courses. Results: The total effective rate (93.33%) in the study group was significantly higher than that in the control group (76.67%), and there was a significant difference between the two groups (P <0.05) (P <0.05), while the levels of IL-2 and IL-10 in treatment group were significantly higher than those before treatment (P <0.05). There was no significant difference in serum TNF-α, IL-2 and IL- Serum levels of TNF-αin the study group were significantly lower than those in the control group (P <0.05), while the levels of IL-2 and IL-10 in the study group were significantly higher than those in the control group (P <0.05) Reaction occurred; study group recurrence rate was significantly lower than the control group (P <0.05). Conclusion: The clinical efficacy of traditional Chinese medicine enema combined with ultrasound in the treatment of patients with chronic pelvic inflammatory disease is significant, and can significantly improve the inflammatory response, reduce the recurrence rate, safe and reliable, and has important research significance.