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应用心钠素放射免疫分析法初步观察了53例风湿性心脏病患者心功能不全时血浆心钠素浓度变化,并探讨与左心房内径的关系。结果发现风心病患者血浆心钠素浓度(337.66±28.34pmol/L)较正常对照组(159.94±5.81pmol/L)显著增高(p<0.001),并且心衰越严重,心钠素水平升高越明显。但有少数(11/53)患者心钠素水平降低。提示血浆心钠素浓度与左心房内径不相关(r=0.238,p>0.05)。首次提出了心衰时心室肌细胞参入代偿性合成与分泌心钠素的假说。
The changes of plasma atrial natriuretic peptide (atrial natriuretic peptide) in 53 patients with rheumatic heart disease (CHF) were studied by atrial natriuretic peptide radioimmunoassay. The relationship between them and the diameter of the left atrium was also discussed. The results showed that the plasma atrial natriuretic peptide concentration in patients with rheumatic heart disease was significantly higher (337.66 ± 28.34 pmol / L) than that in the normal control group (159.94 ± 5.81 pmol / L) (p <0.001) The more obvious. However, a small number (11/53) of patients with decreased levels of atrial natriuretic peptide. Tip plasma atrial natriuretic peptide concentration and left atrial diameter is not related (r = 0.238, p> 0.05). The hypothesis of compensatory synthesis and secretion of atrial natriuretic peptide in ventricular myocytes during heart failure was first proposed.