论文部分内容阅读
目的检测肝炎血清相关标志物水平,探讨该项指标在婴幼儿肝炎综合征中的变化及诊疗价值。方法临床确诊的婴儿肝炎综合征53例,采用全自动化学法分析技术,用杜邦全自动生化分析仪对53例肝炎综合征患儿及38例正常对照组婴幼儿进行血清TBA、ALP、ALT、AST、TBIL、DBIL肝功能指标测定。结果ALT、AST、ALP在该综合征时均值比正常上限升高约2-4倍;DBIL、TBIL升高3-6倍;而TBA则平均升高约8-10倍,患儿组血清TBA(80.84±48.06)μmol/L,异常率达94.3%,与正常对照组有显著性差异;TBA与血清碱性磷酸酶(ALP)、直接胆红素(DBIL)检测水平有良好的相关性。结论TBA的灵敏度和特异性均优于常规指标,血清TBA测定在婴幼儿肝炎综合征的诊断、疗效观察及预后判断中均有重要临床意义,与ALP、DBIL联合检测,更有利于婴儿肝炎综合征的诊疗。
Objective To detect the level of hepatitis related serum markers and to explore the change and diagnosis and treatment of this index in infantile hepatitis syndrome. Methods Fifty-three infants with clinically diagnosed infantile hepatitis syndrome were enrolled in this study. Serum levels of TBA, ALP, ALT and ALP were measured in 53 infants with hepatitis syndrome and 38 normal controls by DuPont automatic biochemical analyzer. AST, TBIL, DBIL liver function test. Results ALT, AST, ALP in the syndrome increased by about 2-4 times the upper limit of normal; DBIL, TBIL increased 3-6 times; while TBA was an average of about 8-10 times increase in children with serum TBA (80.84 ± 48.06) μmol / L, the rate of abnormality was 94.3%, which was significantly different from that of the normal control group. TBA had a good correlation with serum ALP and DBIL. Conclusions The sensitivity and specificity of TBA are better than the conventional ones. Serum TBA has important clinical significance in the diagnosis, curative effect and prognosis of infantile hepatitis syndrome. Combined with ALP and DBIL, serum TBA is more beneficial to infant hepatitis Treatment of levy.