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目的：探讨肾上腺髓质素前体Ｎ端２０肽（ＰＡＭＰ）和肾上腺髓质素（ＡＤＭ）与血管紧张素Ⅱ（Ａｎｇ Ⅱ）之间的相互作用关系。方法：采用离体大鼠主动脉条孵育的方法，在孵育液中分别加入不同浓度（１０－９、 １０－８、１０－７ｍｏｌ／Ｌ）ＡｎｇⅡ，用放射免疫的方法分别测定孵育液中的ｐＡＭＰ、ＡＤＭ浓度，以及大鼠主动脉条组织中 ＰＡＭＰ、ＡＤＭ的含量；另一组在孵育液中分别加入不同浓度（１０－９、１０－８、１０－７ｍｏｌ／Ｌ）ＰＡＭＰ。分别测定孵育液中 以及大鼠主动脉条组织中ＡｎｇⅡ的含量。结果：不同浓度的ＡｎｇⅡ可引起大鼠主动脉条组织中及释放于孵育液 中的ＰＡＭＰ、ＡＤＭ含量成剂量依赖性增加；不同浓度的ＰＡＭＰ对大鼠主动脉条组织中及释放于孵育液中的ＡｎｇⅡ 含量无明显影响。结论：ＡｎｇⅡ可刺激主动脉组织释放和合成 ＰＡＭＰ、ＡＤＭ，此作用可能在心血管的调节中起一 定作用。
Objective: To investigate the interaction between adrenomedullin precursor N-terminal 20 peptide (PAMP) and adrenomedullin (ADM) and angiotensin Ⅱ (Ang Ⅱ). Methods: The aortic strips of isolated rat were incubated with different concentrations (10-9, 10-8, 10-7mol / L) of AngⅡ in the incubation solution. The radioimmunoassay pAMP, ADM concentration, and the content of PAMP and ADM in aortic strips of rats. The other groups were given different concentrations (10-9,10-8,10-7 mol / L) of PAMP in the incubation solution. The contents of AngⅡin the aorta of rat aorta were measured respectively. Results: Different concentrations of AngⅡ could induce PAMP in rat aortic strips and released into the incubation solution in a dose-dependent manner. Different concentrations of PAMP were in rat aortic strips and released into the incubation solution Ang Ⅱ content had no significant effect. Conclusion: Ang Ⅱ can stimulate the release of aortic tissue and synthesis of PAMP, ADM, this effect may play a role in cardiovascular regulation.