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目的:运用Meta分析循证孕妇牙周病与早产低出生体重儿(PLBWI)的关系,为PLBWI的预防控制提供参考依据。方法:搜集国内有关孕妇牙周病与PLBWI关系的前瞻性队列研究和病例对照研究,对数据进行整理和异质性检验后,运用RevMan 5.1统计软件进行Meta分析。结果:共检出相关文献209篇,最终纳入9篇文献(5 361例),其中病例对照研究5篇(4 525例),合并OR=2.84,95%CI:2.07~3.89;队列研究4篇(836例),合并RR=6.38,95%CI:4.11~9.91。采用随机效应模型进行分析后,总效应测定结果显示牙周病孕妇组与正常健康孕妇组PLBWI出生率比较差异有统计学意义(RR=3.12,95%CI:2.02~4.82,Z=5.12,P<0.000 01)。结论:孕妇牙周病可能与早产低出生体重儿的发生具有相关性。
Objective: To provide a reference for the prevention and control of PLBWI by using meta-analysis of the relationship between evidence-based periodontal disease and preterm low birth weight infant (PLBWI). Methods: A prospective cohort study and case-control study on the relationship between periodontal disease and PLBWI in pregnant women in China were collected. Meta-analysis was performed using RevMan 5.1 statistical software after finishing the data and testing the heterogeneity. Results: A total of 209 articles were found and 9 articles were finally included (5 361 cases), of which 5 cases (4 525 cases) were studied as case-control and OR = 2.84,95% CI: 2.07-3.89. (836 cases) with RR = 6.38, 95% CI: 4.11-9.91. The results of total effect analysis showed that there was significant difference in PLBWI birth rate between periodontal disease pregnant women and normal healthy pregnant women (RR = 3.12, 95% CI: 2.02-4.82, Z = 5.12, P < 0.000 01). Conclusion: The periodontal disease in pregnant women may be related to the occurrence of preterm low birth weight infants.