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对侧预防性乳腺切除术(CPM)可降低对侧乳腺癌的发生率,并提高BRCA基因突变乳腺癌患者的生存率,但对早期散发性乳腺癌生存率的影响仍存在争议。近年来CPM的应用逐渐增多,与乳房重建术的实施、基因测试、医师决策等有关。在激素受体阴性的患者中,CPM提高了无病生存率,但现有的研究无法证实其对总生存的影响,CPM的选择须谨慎,其指征可能包括年轻、早期、激素受体阴性患者或患者强烈意愿等。
Contralateral prophylactic mastectomy (CPM) can reduce the incidence of contralateral breast cancer and improve the survival rate of breast cancer patients with BRCA mutations, but the impact on the survival rate of early sporadic breast cancer remains controversial. In recent years, the application of CPM gradually increased, and the implementation of breast reconstruction, genetic testing, physician decision-making and so on. CPM improves disease-free survival in hormone receptor-negative patients, but current studies can not confirm its impact on overall survival. Care should be exercised in selecting CPM and indications may include young, early, androgen receptor-negative Patient or patient strongly wishes.