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目的:探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清中性粒细胞与淋巴细胞比值(serum neutrophil-lymphocyte ratio,NLR)与大血管病变的相关性。方法:将211例T2DM患者分为单纯T2DM(T)组、合并下肢动脉粥样硬化(L)组、合并颈部动脉粥样硬化(C)组、合并下肢动脉兼颈部动脉粥样硬化(LC)组。收集患者的一般临床指标及生化指标。结果:单因素方差分析及LSD多重比较分析显示,L组、C组、LC组的NLR均数均大于T组(P<0.05);Logistic多元回归分析结果显示,年龄、舒张压、低密度脂蛋白胆固醇、NLR是2型糖尿病大血管病变的危险因素(P<0.05)。结论:NLR与2型糖尿病大血管病变存在相关性。
Objective: To investigate the relationship between serum neutrophil-lymphocyte ratio (NLR) and macrovascular disease in type 2 diabetes mellitus (T2DM) patients. Methods: Totally 211 T2DM patients were divided into simple T2DM (T) group, lower extremity atherosclerosis (L) group, combined with atherosclerotic cervical neck (C) group, with lower extremity artery and cervical atherosclerosis LC) group. Collect the general clinical indicators and biochemical indicators of patients. Results: One-way ANOVA and LSD multiple comparisons showed that the NLR of L group, C group and LC group were higher than that of T group (P <0.05). Logistic multiple regression analysis showed that age, diastolic blood pressure, low density lipoprotein Protein cholesterol and NLR were risk factors for type 2 diabetic macroangiopathy (P <0.05). Conclusion: There is a correlation between NLR and type 2 diabetes mellitus.