论文部分内容阅读
目的 :探讨黄芪静脉滴注对慢性乙型病毒性肝炎患者细胞免疫功能的调节作用。方法 :黄芪与甘草酸二胺 (甘利欣 )合用治疗慢性乙型病毒性肝炎轻度 (CL H)及中度 (CMH)患者各 15例 ,并设轻度及中度患者各 10例单用甘利欣治疗作对照 ,另设健康正常组 10例。结果 :治疗组 CD3+ 、CD4+ 和 CD4+ / CD8+ 治后均较对照组显著升高 (P<0 .0 5或 P<0 .0 1)。治疗组CL H型治后自然杀伤 (NK )细胞活性、T淋巴细胞转化率 (L TR)增加 ,血浆可溶性白细胞介素 - 2受体 (SIL - 2 R)水平降低 ,与对照组比较均有显著性差异 (P<0 .0 5 ) ;CMH型与对照组相比无显著变化。结论 :黄芪能显著提高慢性乙型病毒性肝炎患者的细胞免疫功能 ,对轻度患者的疗效优于中度患者。
Objective: To investigate the regulation effect of intravenous injection of Astragalus on cellular immune function in patients with chronic hepatitis B virus. Methods: Astragalus and glycyrrhizic acid diamine (Glycyrrhizin) combined treatment of mild hepatitis B mild (CL H) and moderate (CMH) in patients with 15 cases, and mild and moderate patients were treated with 10 cases of single Glycyrrhizin treatment as control, another set of normal group of 10 patients. Results: After treatment, the levels of CD3 +, CD4 + and CD4 + / CD8 + in treatment group were significantly higher than those in control group (P <0.05 or P <0.01). After treatment with CL H, the activity of natural killer (NK) cells, the increase of T lymphocyte transformation rate (L TR) and the level of soluble interleukin - 2 receptor (SIL - 2 R) in the treatment group were lower than those in the control group Significant difference (P <0. 05); CMH type compared with the control group no significant change. Conclusion: Radix Astragali can significantly improve the cellular immune function in patients with chronic hepatitis B, and is superior to moderate patients in mild patients.