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目的:探讨PTEN基因与新疆维族妇女宫颈病变的相关关系。方法:选取维吾尔族妇女正常或炎症的宫颈组织30例、CINⅠ30例、CINⅡ/Ⅲ30例、宫颈鳞癌组织30例采用免疫组化SP法检测PTEN蛋白表达。结果:PTEN的蛋白表达率在正常或炎症的宫颈组织、CINⅠ、CINⅡ/Ⅲ、宫颈鳞癌组织中分别为83.3%、73.3%、56.7%、23.3%,SCC组阳性表达率明显减少,与前三组有显著性(P<0.05)。结论:新疆维族妇女宫颈病变组织中PTEN蛋白水平表达减少,其与新疆维族妇女宫颈病变呈负相关关系;是宫颈组织恶变的信号。
Objective: To investigate the relationship between PTEN gene and Uygur women with cervical lesions in Xinjiang. Methods: Thirty cases of normal or inflammatory cervical tissue from 30 Uyghur women were selected. The expression of PTEN protein in 30 cases of CINⅠ, 30 cases of CINⅡ / Ⅲ and 30 cases of cervical squamous cell carcinoma were detected by immunohistochemistry SP method. Results: The positive rate of PTEN protein expression was 83.3%, 73.3%, 56.7% and 23.3% in normal and inflammatory cervical tissues, CINⅠ, CINⅡ / Ⅲ and cervical squamous cell carcinoma respectively. Three groups were significant (P <0.05). CONCLUSION: The expression of PTEN protein in Uighur women with cervical lesions is decreased, which is negatively correlated with Uighur women with cervical lesions in Xinjiang Uighur. It is a signal of cervical malignant transformation.