前言:在神经组织中存在麻醉性镇痛药的受体(阿片受体),自1971年 Goldstein 等研究以来,已被许多研究组所证实。其后成为人们注目的焦点,并对该物质做了提取、精制的试验。最初称它为类吗啡样因子(MLF),后来由于阐明了它的本质是肽类,故又称吗啡样肽类(阿片类肽)或内啡肽。此种物质的生理、药理的意义还不十分清楚,现将迄今的研究情况介绍如下。 Introduction: The presence of narcotic analgesic receptors (opioid receptors) in nerve tissue has been demonstrated by many groups since the 1971 Goldstein et al. Study. Subsequent to become the focus of attention, and made the material extraction, refined test. Originally called morphine-like factor (MLF), morphine-like peptides (opioid peptides) or endorphins are also known as elucidating their nature as peptides. The physical, pharmacological significance of such substances is not yet clear, the research so far described below are as follows.