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在人体内,氨基-β-内酰胺类抗生素均能很好地被小肠吸收。一般认为头孢菌素类对肠细胞膜的透过能力取决于(1)小肠通过上皮细胞纹缘膜摄取药物的能力。(2)药物在胞浆中的扩散能力。(3)药物透过偏碱性的细胞膜进入血液的能力。其中尤以第一点为最重要。作者研究了头孢菌素类的肠内吸收率,与它们的透过上皮细胞纹缘膜能力之间的关系。肠内吸收率测定用体重180~220g的雄性Wistar大白鼠,在禁饲16~20h后,腹腔注射戊巴比妥40mg/kg麻醉,取全段小肠标本进行肠袢吸收率测定。肠袢的洗涤和头孢
In the human body, amino-β-lactam antibiotics are well absorbed by the small intestine. It is generally accepted that the ability of cephalosporins to permeate intestinal cell membranes depends on (1) the ability of the small intestine to ingest drugs through epithelial cell lines. (2) Drugs in the cytoplasm of the proliferation capacity. (3) The ability of the drug to enter the bloodstream through an alkaline cell membrane. Especially the first point is the most important. The authors investigated the relationship between cephalosporin enteral absorption and their ability to penetrate the epithelial lining of the epithelium. Intestinal absorption rate determination Male Wistar rats weighing 180-220 g were anesthetized by intraperitoneal injection of pentobarbital 40 mg / kg after forbidden feeding for 16-20 h, and the intestinal segments were taken for determination of intestinal absorption rate. Wash bowel and cephalosporin