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本文复习左旋多巴和金刚胺的临床研究,确定它们的最合适的用法。大多数震颤麻痹病人对左旋多巴治疗有反应,60％的病人的全部主要症状中有一半以上得到改善,对运动不能和僵直的症状有持久的减轻,而持续的治疗亦使震颤有显著的改善。本药比抗胆硷疗法还有效3.5倍。对伴有严重丧失活动能力、严重精神错乱和抑郁症的病人的疗效较差。常见副作用有恶心、呕吐、厌食、异常运动、体位性低血压、行为异常等。在小剂量时发生这些副作用是治疗失败的最常见的原因,一般脑炎后病人不能耐受如原发性病人所能耐受那样大剂量的左旋多巴。左旋多巴治疗失败的另一个
This article reviews the clinical studies of levodopa and amantadine to determine their most appropriate use. Most patients with Parkinsonism respond to treatment with levodopa, and improvement in more than half of all major symptoms in 60% of patients has a sustained reduction in symptoms of immobility and stiffness while continued treatment also causes significant tremor improve. The drug is more effective than anti-cholinergic therapy 3.5 times. Patients with severe incapacity, severe mental disorder and depression are less effective. Common side effects are nausea, vomiting, anorexia, abnormal exercise, orthostatic hypotension, abnormal behavior and so on. These side effects at low doses are the most common causes of treatment failure and generally post-encephalitis patients can not tolerate the high doses of levodopa that primary patients can tolerate. Levodopa Another failed treatment