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目的系统评价中西医结合疗法预防原发性肝癌术后复发的效果。方法计算机检索The Cochrane Library、PubMed、EMbase、中国期刊全文数据库(CNKI)、中文科技期刊数据库(VIP)、万方数据库(Wanfang Data)等数据库,收集所有中西医结合预防原发性肝癌术后复发的随机对照试验(RCT),检索时限均从建库至2013年6月。由2名评价员严格按照纳入标准筛选文献、提取资料和评价质量后,采用RevMan5.2软件对数据进行Meta分析。结果纳入文献共5篇,总病例数367例。Meta分析显示,中西医结合组在1、2、3年复发率控制方面均优于对照组(单纯西医治疗组),差异均有统计学意义(P<0.05)。结论与单纯的西医治疗组比较,中西医结合疗法在预防原发性肝癌术后复发方面效果更显著。
Objective To systematically evaluate the effect of combining traditional Chinese and western medicine in preventing postoperative recurrence of primary liver cancer. Methods The databases of The Cochrane Library, PubMed, EMbase, Chinese Journal Full-text Database (CNKI), Chinese Science and Technology Periodical Database (VIP) and Wanfang Data were searched by computer, and all the traditional Chinese and Western medicines were collected to prevent postoperative recurrence of primary liver cancer Of randomized controlled trials (RCTs), search time from the database to June 2013. Two reviewers screened the literature strictly according to inclusion criteria, extracted data and evaluated the quality, and then used RevMan5.2 software to do the data analysis. Results included in the literature a total of 5 articles, the total number of cases 367 cases. Meta - analysis showed that the combination of TCM and WM was superior to the control group (WM group only) in the control of recurrence in 1, 2 and 3 years (P <0.05). Conclusion Compared with the simple western medicine treatment group, the combined traditional Chinese and western medicine treatment is more effective in preventing postoperative recurrence of primary liver cancer.