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目的评价蓝光联合茵栀黄颗粒治疗新生儿病理性黄疸的临床疗效及安全性。方法入选病理性黄疸患儿150例,随机分为试验组和对照组,每组75例。对照组常规对症治疗,加间断蓝光光疗,试验组在对照组治疗基础上加用茵栀黄颗粒,每次1 g,每天3次,7 d为1个疗程,比较2组患儿治疗前,治疗后1,3,7 d血清胆红素变化情况、临床疗效以及不良反应。结果 2组患者治疗后较治疗前血清胆红素水平呈下降趋势(P<0.05),试验组血清胆红素水平恢复正常时间为(5.58±2.16)d,明显短于对照组的(10.82±3.54)d(P<0.05);住院时间(7.28±3.24)d,明显短于对照组的(12.64±4.85)d(P<0.05)。试验组痊愈率、总有效率分别为33.33%,94.67%,明显高于对照组的18.67%,72.00%(P<0.05,P<0.01)。2组均未发生严重不良反应。结论间断蓝光光疗联合茵栀黄颗粒治疗能快速降低血清胆红素水平,疗效确切且安全性高。
Objective To evaluate the clinical efficacy and safety of blue light combined with Yinzhihuang granule in the treatment of neonatal pathological jaundice. Methods 150 cases of pathological jaundice children were randomly divided into experimental group and control group, 75 cases in each group. Control group conventional symptomatic treatment, plus intermittent Blu-ray phototherapy, the experimental group in the control group based on the use of Yinzhihuang granules, each 1 g, 3 times a day, 7 d for a course of treatment, compared two groups of children before treatment, Serum bilirubin changes at 1, 3 and 7 days after treatment, clinical efficacy and adverse reactions. Results The serum bilirubin level in both groups decreased after treatment (P <0.05), and the serum bilirubin level returned to normal in the experimental group (5.58 ± 2.16) days, which was significantly shorter than that in the control group (10.82 ± 3.54) d (P <0.05). The length of hospital stay (7.28 ± 3.24) d was significantly shorter than that of the control group (12.64 ± 4.85) d (P <0.05). The cure rate and total effective rate in the experimental group were 33.33% and 94.67%, respectively, which were significantly higher than those in the control group (18.67%, 72.00%, P <0.05, P <0.01). No serious adverse reactions occurred in both groups. Conclusion Intermittent Blu-ray phototherapy combined with Yinzhihuang granule can rapidly reduce the level of serum bilirubin. The curative effect is accurate and safe.