目的:研究低流量吸入地氟醚对患儿自身压力反射敏感性产生的影响。方法:取我院收治Ⅰ~Ⅱ级患儿66例作为研究对象,依据维持麻醉方式差异,分为A组(n=33)与B组(n=33),A组予以地氟醚,B组予以异氟醚,均实施低流量吸入法,对比两组各时间点心血管BRS、翻身后升至目标血压时间、复苏时间及术后不良反应产生情况。结果:同时刻,两组心血管BRS、术后一天内恶心呕吐率对比差异无统计学意义(P>0.05);组内对比:相比于T0,两组T_1、T_2、T_3及T_4时刻心血管BRS均显著减小(P<0.05);相比于T_1,两组T_2、T_3时刻心血管BRS均显著增加(P<0.05);相比于T_2,两组T_4时刻心血管BRS显著减小(P<0.05);相比于T_3,两组T_4时刻心血管BRS显著减小(P<0.05);A组翻身后升至目标血压时间、睁眼时间及指令伸舌时间均明显短于B组(P<0.05)。结论:对患儿以低流量吸入方式给予地氟醚与异氟醚,均能产生良好控制性降压效果,其中地氟醚可促进患儿快速复苏,安全性较高,具有积极应用价值。 Objective: To study the effect of inhaled desflurane on the self-reflex sensitivity of children. Methods: A total of 66 children with grade Ⅰ ~ Ⅱ in our hospital were enrolled in this study. Patients in group A (n = 33) and group B (n = 33) were divided into two groups according to the way of maintaining anesthesia. Group A received desflurane, Group were given isoflurane, were administered low-flow inhalation method, comparing the two groups at each time point of cardiovascular BRS, erected after rising to the target blood pressure time, recovery time and postoperative adverse reactions. Results: At the same time, there was no significant difference in the rate of cardiovascular BRS and nausea and vomiting in one day after operation (P> 0.05). Compared with T0, T_1, T_2, T_3 and T_4 (P <0.05). Compared with T 1, the levels of BRS in both groups at T 2 and T 3 were significantly increased (P <0.05). Compared with T 2, the levels of BRS in T 2 at both groups were significantly decreased (P <0.05). Compared with T_3, the BRS of both groups were significantly decreased at T_4 (P <0.05); the time to stand-up and target blood pressure of group A were significantly shorter than those of B Group (P <0.05). CONCLUSIONS: Both desflurane and isoflurane given by low-flow inhalation to children can produce good controlled hypotensive effect. Desflurane can promote the rapid recovery of children with high safety and has positive application value.