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患过原发性甲状腺功能减退(甲减)的病人可以发生甲状腺功能亢进(甲亢),这种情况很有意义,但不多见。作者报告6例有关资料。6例患者(女性5例,男性1例),诊断甲减时的年龄为20～66(平均46)岁。诊断为甲亢时的年龄为30～70(平均53)岁。起初,全部病人均有甲减症状,5例无甲状腺肿大,1例不明确。5例有甲减的生化指标,1例无有关资料。诊断甲减后,除1例外均用甲状腺素(T_4)治疗。诊断为甲亢时所有病人至少在半年内未用(T_4).从甲减到出现甲亢的间期为2～20(平均8)年。全部患者均有甲亢症状,甲状腺肿大,触诊局部有震颤.3例有眼球突出。仅2例血清总(T_4)浓度升高,其余4例正常。血清甲状腺素结合球蛋白均正常,5
Hyperthyroidism (hyperthyroidism) can occur in patients with primary hypothyroidism (hypothyroidism), a condition that is significant but infrequent. The author reports 6 cases of relevant information. Six patients (5 females and 1 males) had a diagnosis of hypothyroidism with a mean age of 20-66 (mean 46 years). The diagnosis of hyperthyroidism when the age of 30 to 70 (average 53) years old. At first, all patients had hypothyroidism, 5 had no goiter, and 1 had no definite answer. 5 cases had hypothyroidism biochemical indicators, 1 case no relevant information. After the diagnosis of hypothyroidism, with 1 exception were treated with thyroxine (T_4). All patients diagnosed as hyperthyroidism unused at least within six months (T_4). From hypothyroidism to hyperthyroidism occurred between 2 to 20 (average 8) years. All patients had symptoms of hyperthyroidism, goiter, palpation of local tremor in 3 cases with prominent. Only two cases of serum total (T_4) concentration increased, the remaining four cases of normal. Serum thyroxine binding globulin are normal, 5