已有报导注射纳洛酮和阿片肽影响学习与记忆,并推想内源性阿片肽可能与此有关。本工作试图从以下实验探讨内源性脑啡肽参与记忆巩固调制的可能性:1.在肯定纳洛酮和甲啡肽对记忆有作用的基础上,观察二者之间的互相影响。2.观察氨基肽酶(脑啡肽降解酶之一)抑制剂bestatin对记忆是否有影响。3.纳洛酮对记忆的影响与肾上腺髓质内分泌的关系。 Injection of naloxone and opioids has been reported to affect learning and memory, and it is assumed that endogenous opioid peptides may be involved. This work attempts to explore the possibility of endogenous enkephalins involved in memory consolidation modulation from the following experiment: 1. On the basis of confirming the memory effect of naloxone and methamide on the memory, observe the mutual influence between the two. 2. To observe whether aminopeptidase (one of the enkephalin degrading enzymes) inhibitor bestatin has an effect on memory. 3. Naloxone on memory and the relationship between adrenal medulla endocrine.