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作者从植物Soulamea tementosa的叶中分离得一个具有抗白血病活性的新的苦木内酯soularubin-one。取该植物干燥叶700g,用己烷在室温脱脂后加入70～75°热水并搅拌数小时,过滤,再用新鲜热水同上操作几次,直至滤出液无明显苦味为止,合并水提取液,浓缩后用氯仿连续萃取后得提取物9.6g,以硅胶400g装柱层析,以逐渐增加甲醇量(1～8%)的氯仿液洗脱,先后获得6个化合物,其中5个经与标准品对照后鉴定为已知苦木内酯异鸦胆子苦素A(Isobrucein A),黄楝苦素B(Picrasin B),6-羟基黄楝苦素B,卡帕里酮
The authors isolated a new anti-leucovorin soularubin-one from the leaves of the plant Soulamea tementosa. Take the plant dried leaves 700g, degreasing with hexane at room temperature after adding 70 ~ 75 ° hot water and stirred for several hours, filtered, and then fresh hot water same operation several times until the filtrate no significant bitterness, the combined water extraction The solution was concentrated by chloroform, and then 9.6 g of the extract was obtained. The residue was purified by column chromatography on a 400 g silica gel column and gradually eluted with a chloroform solution of methanol (1-8%). Six compounds were obtained one after the other, Compared with the standard, it was identified as Isobrucein A, Picrasin B, 6-hydroxyquartzin B,