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目的 研究胎胰移植对I型糖尿病肾病患者行肾移植的影响。方法 我院近 2年多来在I型糖尿病患者肾移植手术前行胎胰组织移植 (移植组 ) 43例 ,并与同期未行胎胰移植的肾移植手术患者 76例 (对照组 )进行比较。结果 移植组 43例中有 2 7例术后胰岛素用量减少 >5 0 % ,持续 3个月以上 (62 .8% ) ,其中有 4例持续已达 2年 ,1例完全停用胰岛素 ;术后 2周内血清胰岛素水平升高 >10 0U /ml的 3 6例 (83 .7% ) ;术后血清C肽升高 >0 .5ng/ml的共 3 4例 (79.1% )。移植组术后生存率及完全恢复工作能力的比率均明显高于对照组。结论 对行肾移植术的I型糖尿病肾病患者 ,肾移植术前先行胎胰移植可提高I型糖尿病性肾功能衰竭患者肾移植术后的疗效
Objective To study the effect of fetal and pancreatic transplantation on renal transplantation in patients with type 1 diabetic nephropathy. Methods Forty-three cases of fetal pancreatic tissue transplantation (transplantation group) before kidney transplantation in type I diabetic patients in our hospital for the past two years or more were compared with 76 cases (control group) of patients without kidney transplantation undergoing fetal pancreas transplantation in the same period . Results In the transplantation group, 27 cases of postoperative insulin dosage decreased> 50% for more than 3 months (62.8%), of which 4 cases lasted for 2 years and 1 case completely stopped using insulin There were 34 cases (79.1%) of 36 patients (83.7%) with elevated serum insulin level> 10 0U / ml within 2 weeks and postoperative serum C-peptide> 0.5ng / ml. The postoperative survival rate and complete recovery of working ability of the transplantation group were significantly higher than the control group. Conclusions For patients with type 1 diabetic nephropathy who underwent renal transplantation, prenatal transplantation of fetal pancreas and pancreaticoduodenectomy before renal transplantation can improve the efficacy of renal transplantation in patients with type 1 diabetic renal failure