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目的探讨血管生成素4(Ang-4)在大肠癌的表达和肿瘤生长的关系。方法采用免疫组织化学方法,检测48例大肠癌、25例正常肠组织中Ang-4蛋白的表达,以CD34单克隆抗体标记血管内皮细胞,并计数微血管密度(MVD)。结果 Ang-4在大肠癌组的表达为75.0%,明显高于对照组(24.0%),差异有统计学意义(P<0.01);大肠癌组Ang-4表达与MVD成正相关(r=0.577,P<0.01)。结论 Ang-4在大肠癌中的过度表达提示其在肿瘤血管新生、促进肿瘤的发生发展起重要作用。
Objective To investigate the relationship between the expression of angiopoietin-4 (Ang-4) in colorectal carcinoma and tumor growth. Methods Immunohistochemistry was used to detect the expression of Ang-4 protein in 48 cases of colorectal carcinoma and 25 cases of normal intestinal tissue. The endothelial cells were labeled with CD34 monoclonal antibody and the microvessel density (MVD) was counted. Results The expression of Ang-4 in colorectal carcinoma was 75.0%, which was significantly higher than that in control group (24.0%), the difference was statistically significant (P <0.01). The expression of Ang-4 in colorectal carcinoma was positively correlated with MVD , P <0.01). Conclusion The overexpression of Ang-4 in colorectal cancer suggests that Ang-4 plays an important role in tumor angiogenesis and tumorigenesis.