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目的探讨老年人脑梗死相关危险因素,为临床预防和治疗提供客观依据。方法 1998～2009年乌鲁木齐有色医院收治的老年人(年龄>60岁)记录性别、年龄、血压、病史(包括糖尿病、高血压、高脂血症、高尿酸血症)以脑CT或MRI的检查结果分为脑梗死组(实验组)和非脑梗死组(即对照组);合并有其他脑血管病的病例不在本项研究的入选中,有服用降脂药物的患者,停服降脂药物2周后再检测血液的生化指标;两组病人的血液生化指标均采用美国贝克曼全自动生化仪测定。结果脑梗死组病人同时合并高血压的发生率显著高于对照组(P<0.05),两组的胆固醇、甘油三脂、高密度脂蛋白、载脂蛋白A、载脂蛋白B和血尿酸指标无统计学意义的差别(P>0.05),舒张压、低密度脂蛋白和血糖有显著性差别(P<0.01和P<0.05)。结论高血压作为脑梗死的独立危险因素是老年人防治脑梗死的重点内容。降压、降低LDL或提升HDL/LDL比值以及防治胰岛素抵抗对防治老年人脑梗死有积极的意义。
Objective To explore the risk factors related to cerebral infarction in the elderly and provide an objective basis for clinical prevention and treatment. Methods The age, age, blood pressure, history (including diabetes mellitus, hypertension, hyperlipidemia and hyperuricemia) in Urumqi Nonferrous Hospital from 1998 to 2009 were examined by brain CT or MRI The results were divided into cerebral infarction group (experimental group) and non-cerebral infarction group (control group); combined with other cerebrovascular disease cases are not included in the study selected patients taking lipid-lowering drugs to stop taking lipid-lowering drugs Two weeks later, the biochemical indexes of blood were tested again. The blood biochemical indexes of two groups of patients were determined by Beckman automatic biochemical analyzer. Results The incidence of concurrent hypertension in patients with cerebral infarction was significantly higher than that in the control group (P <0.05). The levels of cholesterol, triglyceride, high density lipoprotein, apolipoprotein A, apolipoprotein B and serum uric acid No significant difference (P> 0.05), diastolic blood pressure, low density lipoprotein and blood glucose were significantly different (P <0.01 and P <0.05). Conclusion Hypertension as an independent risk factor for cerebral infarction is the focus of prevention and treatment of cerebral infarction in the elderly. Antihypertensive, lower LDL or increase HDL / LDL ratio and prevention and treatment of insulin resistance in the prevention and treatment of cerebral infarction in the elderly have a positive meaning.