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目的:评价依那普利与螺内酯联用对老年慢性心力衰竭(CHF)患者心室重构及生活质量的影响。方法:选取2014年3月—2016年7月间收治的老年CHF患者102例,根据入院时间顺序将其分为对照组和观察组,每组51例;对照组患者给予常规抗心力衰竭药物治疗,观察组患者在对照组基础上加用依那普利和螺内酯治疗;比较两组患者治疗前后左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)、心室舒张晚期充盈速度最大值(A峰)、心室舒张早期充盈速度最大值(E峰)改善情况及生活质量评分值的变化情况。结果:观察组患者治疗后E峰值高于对照组(P<0.05),LVEDD、LVESD、A峰值低对照组(P<0.05);治疗后观察组患者生活质量评分值显著低于对照组(P<0.05)。结论:依那普利与螺内酯联用对改善老年CHF患者心室重构的效果较为明显,同时也提高了患者的生活质量。
Objective: To evaluate the effects of enalapril and spironolactone on ventricular remodeling and quality of life in elderly patients with chronic heart failure (CHF). Methods: A total of 102 CHF patients aged from March 2014 to July 2016 were selected and divided into control group and observation group according to the order of admission. Each group included 51 patients. Patients in control group were given conventional anti-heart failure drug treatment The patients in the observation group were treated with enalapril and spironolactone on the basis of the control group. The changes of left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), and maximum late diastolic filling velocity A peak), the maximum value of early diastolic filling velocity (E peak) and quality of life score changes. Results: After treatment, the E peak of treatment group was significantly higher than that of control group (P <0.05), LVEDD, LVESD and A peak of low control group (P <0.05). After treatment, the quality of life score of observation group was significantly lower than that of control group <0.05). Conclusion: The combination of enalapril and spironolactone improves the ventricular remodeling in elderly patients with CHF, and improves the quality of life of patients.