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动物整体水平研究证实，八肽胆囊收缩素抗血清（ＣＣＫ－ＡＳ）可翻转电针耐受，而ＣＣＫ－ＡＳ本身不影响基础痛阈。本文采用记录神经元放电的方法证明：脑室注射ＣＣＫ－ＡＳ能翻转对长时间电针产生耐受效应的大鼠丘脑束旁核痛兴奋神经元（ＰＥＮ）和痛抑制神经元（ＰＩＮ）的电活动，使电针镇痛效应重新出现。而脑室注射正常兔血清（ＮＲＳ）对产生电针耐受效应的ＰＥＮ和ＰＩＮ的电活动无影响。从细胞水平得到的这一结果与整体水平研究的证据相一致。提示，内源性ＣＣＫ－８参与电针耐受可能是电针镇痛受到拮抗的机制之一。这一发现同时为临床医学实践提供了进一步的依据。
Overall animal studies confirm that octapeptide cholecystokinin antiserum (CCK-AS) reverses electro-acupuncture tolerance, whereas CCK-AS itself does not affect basal pain threshold. In this paper, the method of recording neuronal discharge was used to demonstrate that intracerebroventricular injection of CCK-AS can reverse the electrical activity of pain-excitation neurons (PEN) and pain-suppressing neurons (PIN) in rat thalamic parafascicular nuclei Activity, the electroacupuncture analgesic effect reappears. Intraventricular injection of normal rabbit serum (NRS) had no effect on the electrical activity of PEN and PIN that produced electrical needle tolerance. This result, obtained at the cellular level, is consistent with evidence from overall level studies. Tip, endogenous CCK-8 involved in electroacupuncture may be one of the mechanisms by which electroacupuncture analgesia is antagonized. This finding also provides a further basis for clinical practice.