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目的探讨高尿酸与2型糖尿病患者心功能及血脂的关系。方法选取本院167例2型糖尿病患者,分别检测空腹血糖(FBG),磷酸肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH),甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)等指标,依据尿酸水平分为高尿酸组和正常组。结果高尿酸组及正常尿酸组比例在男女性别中差异无统计学意义(χ2=0.001,P=0.96>0.05)。高尿酸组患者FBG值与正常尿酸组相比,其差异无统计学意义(P=0.23>0.05)。高尿酸组中CK、CK-MB、LDH值与正常尿酸组相比差异均具有统计学意义(P=0.007、0.020、0.003<0.05)。高尿酸组中TG、TC、HDL-C测定值与正常尿酸组相比较,差异均无统计学意义(P=0.64、0.31、0.88>0.05)。结论高尿酸在2型糖尿病患者中发生心功能损害起着重要作用,而对血脂的影响则可能起着双向作用。
Objective To investigate the relationship between hyperuricemia and heart function and blood lipid in type 2 diabetic patients. Methods A total of 167 patients with type 2 diabetes mellitus (T2DM) were enrolled in this study. Fasting plasma glucose (FBG), creatine phosphokinase (CK), creatine kinase (CK), lactate dehydrogenase (LDH) (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and other indicators, according to uric acid levels were divided into high uric acid group and normal group. Results The ratio of high uric acid group and normal uric acid group had no significant difference between men and women (χ2 = 0.001, P = 0.96> 0.05). There was no significant difference in FBG between hyperuricemia group and normal uric acid group (P = 0.23> 0.05). Compared with normal uric acid group, CK, CK-MB and LDH in hyperuricemia group were significantly different (P = 0.007,0.020,0.003 <0.05). There was no significant difference in TG, TC and HDL-C between hyperuricemia group and normal uric acid group (P = 0.64,0.31,0.88> 0.05). Conclusions Hyperuricemia plays an important role in the development of cardiac dysfunction in patients with type 2 diabetes, while its effect on blood lipids may play a bidirectional role.