研究表明缺血性脑损伤病理进展经历一段较长的时间 ,数小时到数日不等 ,在缺血中心区 ,血流减少最严重 ,能量衰竭 ,随后迅速发生细胞坏死 ,然而 ,在缺血周围区域 ,神经元细胞存活时间相对较长 ,有的可达数日。迄今为止 ,大多数研究集中在脑缺血的急性期 ,对于梗塞周围区域 (也 Studies have shown that the pathological progression of ischemic brain injury has been going through a long period of time ranging from hours to days. In the ischemic center, the blood flow is most severely reduced and energy depleted, followed by rapid cell necrosis. However, Surrounding areas, neuronal cell survival time is relatively long, some up to several days. To date, most studies have focused on the acute phase of cerebral ischemia, for the area around the infarct