红细胞生成素(Erythropoietin,ESF)产生的主要部位在肾脏,而引起其产生的基本刺激乃为肾近球细胞的缺氧。已知当动物暴露于低气压或由于贫血性缺氧时,交感神经活动普遍增加。因此,似乎改变交感活动能影响缺氧时红细胞生成的反应。曾有报导关于狗注入去甲肾上腺素后提高血浆 ESF 水平,以及从周围或中枢性途经阻断肾脏交感神经传出道能减少低氧下红细胞生成的反应。也有报导称低氧导 Erythropoietin (ESF) produces a major site in the kidneys, and the underlying stimulus is the hypoxia in the kidney proximal cells. It is known that sympathetic activity generally increases when an animal is exposed to depression or due to anemic hypoxia. Therefore, it seems that changing the sympathetic activity can affect erythropoiesis response during hypoxia. There have been reports of an increase in plasma ESF levels following noradrenaline injection in dogs and a reduction of hypoxemic erythropoiesis in peripheral or central pathways that block the renal sympathetic pathways. There are also reports of hypoxia