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目的探讨壹期煤工尘肺(CWP)患者血清趋化因子γ-干扰素诱导蛋白10(IP-10)、巨噬细胞炎症蛋白-1α(MIP-1α)、巨噬细胞炎症蛋白-1β(MIP-1β)和巨噬细胞炎症蛋白-3α(MIP-3α)水平变化及意义。方法用Luminex流式荧光技术检测85例壹期CWP患者(CWP组)、44例井下健康工人(接尘对照组)及42例井上健康工人(正常对照组)血清IP-10、MIP-1α、MIP-1β和MIP-3α水平。结果与正常对照组比较,CWP组IP-10升高、MIP-1α降低,接尘组IP-10、MIP-1α和MIP-1β均降低,差异均有统计学意义(P<0.01,P<0.05);CWP组IP-10、MIP-1α、MIP-1β和MIP-3α水平均明显高于接尘对照组,差异具有统计学意义(P<0.01,P<0.05);与单纯CWP比较,CWP合并肺气肿患者MIP-3α水平下降,差异具有统计学意义(P<0.05)。CWP患者血清IP-10与MIP-1α、MIP-1β、MIP-3α以及MIP-1α和MIP-1β呈轻度正相关(rs=0.452、0.363、0.255、0.501,P<0.05)。结论壹期CWP患者血清趋化因子IP-10、MIP-1α、MIP-1β和MIP-3α水平异常,与尘肺发生发展有关;检测MIP-3α水平可能反映CWP病情程度。
Objective To investigate the expressions of serum chemotactic factor-interferon-inducible protein 10 (IP-10), macrophage inflammatory protein-1α (MIP-1α), macrophage inflammatory protein-1β -1β) and macrophage inflammatory protein-3α (MIP-3α) levels and their significance. Methods Serum levels of IP-10, MIP-1α, TNF-α and IL-6 in 85 patients with CWP (CWP group), 44 healthy workers (dust control group) and 42 healthy workers (normal control group) were detected by Luminex flow cytometry. MIP-1β and MIP-3α levels. Results Compared with the normal control group, the levels of IP-10 and MIP-1α in CWP group were decreased and the levels of IP-10, MIP-1α and MIP-1β in the dust-exposed group were significantly lower than those in the normal control group (P <0.01, 0.05). The levels of IP-10, MIP-1α, MIP-1β and MIP-3α in CWP group were significantly higher than those in control group (P <0.01, P < The level of MIP-3α in CWP complicated with emphysema decreased significantly (P <0.05). There was a mild positive correlation between IP-10 and MIP-1α, MIP-1β, MIP-3α, MIP-1α and MIP-1β in CWP patients (rs = 0.452,0.363,0.255,0.501, P <0.05). Conclusions The levels of serum chemokines IP-10, MIP-1α, MIP-1β and MIP-3α in the first phase of CWP are abnormal, which is related to the development of pneumoconiosis. Detecting the level of MIP-3α may reflect the severity of CWP.