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圆锥角膜的病因尚不清楚。但是,早期的研究报道显示,在圆锥角膜患者中存在镁缺乏,提示镁缺乏可能导致角膜病理性的改变。回顾近年来有关圆锥角膜与镁缺乏的实验及临床研究资料。研究显示,圆锥角膜在分子学及细胞学上的改变,包括膜变薄甚至破裂、细胞和胶原纤维的变性、线粒体肿胀以及蛋白合成异常。镁缺乏会导致类似的改变。现就圆锥角膜的特异性改变与镁缺乏引起的细胞水平的改变之间相关性作一介评。
The cause of keratoconus is not clear. However, earlier studies have shown magnesium deficiency in patients with keratoconus, suggesting that magnesium deficiency may lead to pathological changes in the cornea. Review of recent years, experimental and clinical data on keratoconus and magnesium deficiency. Studies have shown that molecular changes in keratoconus and cytology, including membrane thinning or even rupture, degeneration of cells and collagen fibers, mitochondria swelling and protein synthesis abnormalities. Magnesium deficiency can cause similar changes. Now on the specific changes in keratoconus and magnesium deficiency caused by changes in the correlation between the level of cells make an introduction.