我国研制的新型抗菌药吡哌酸[8-乙-5,8-2氢-5-氧-2-(1-哌嗪)吡啶并嘧啶-6-羧酸]于1981年正式投产,经过几年的临床试用证明,吡哌酸是一种抗菌效果较好的药物,在临床治疗中有一定的应用价值。吡哌酸对革兰氏阴性细菌有较好的抑菌和杀菌作用,对大肠杆菌、痢疾杆菌、变形杆菌和绿脓杆菌等有显著的抗菌作用。其抗菌活性强于萘啶酸、头孢立新、氨苄青霉素等。与羧苄青霉素有协同作用。吡哌 China’s development of a new antibacterial drug pipemidic acid [8-B-5,8-2 hydrogen -5-oxo-2- (1-piperazine) pyridopyrimidine-6-carboxylic acid] officially put into operation in 1981, after a few Years of clinical trial proved that pipemidic acid is a good antimicrobial effect of drugs, in clinical treatment has a certain value. Pipemidic acid has good antibacterial and bactericidal activity against Gram-negative bacteria, and has significant antibacterial activity against Escherichia coli, Shigella dysenteriae, Proteus and Pseudomonas aeruginosa. Its antibacterial activity is stronger than nalidixic acid, cefprozil, ampicillin and so on. Synergistic effect with carbenicillin. Pyripropene