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应用酶联亲和组化法对54例食管鳞状上皮癌及12例正常食管粘膜进行雌激素受体和孕激素受体检测。结果表明,食管鳞状上皮癌的雌激素受体阳性率为42.6%,孕激素受体阳性率为37.0%。正常食管粘膜均为阴性。提示食管鳞状上皮癌中确有雌激素受体及孕激受体存在,同时其阳性率与组织学分级、性别有明显关系,而与病理形态、年龄、淋巴结转移无关。该研究为选择性应用内分泌治疗食管鳞状上皮癌提供了理论依据。
The estrogen and progesterone receptors were detected in 54 cases of esophageal squamous cell carcinoma and 12 cases of normal esophageal mucosa by enzyme-linked immunohistochemistry. The results showed that the positive rate of estrogen receptor in esophageal squamous cell carcinoma was 42.6%, and the positive rate of progesterone receptor was 37.0%. Normal esophageal mucosa were negative. The presence of estrogen and pregnancy receptors in esophageal squamous epithelial carcinoma was confirmed, and the positive rate was correlated with histological grade and sex, but not with pathology, age, and lymph node metastasis. This study provides a theoretical basis for the selective application of endocrine therapy for esophageal squamous cell carcinoma.