汉坦病毒是朝鲜出血热——一种严重的肾病综合征出血热(HFRS)的致病因子。该病毒的核酸为一条单链RNA,由三部分组成:编码核衣壳蛋白(N)的小片段(S)、编码两种包膜糖蛋白(G_1、G_2)的中等大小片段(M)和编码与毒粒相关的聚合酶的大片段(L)。本文报道两种可能用于人体的HFRS重组痘苗病毒疫苗的构建。为便于筛选,作者最初构建的痘苗病毒 Hantaan virus is North Korean hemorrhagic fever, a causative agent of severe hemorrhagic fever with nephrotic syndrome (HFRS). The virus nucleic acid is a single-stranded RNA consisting of three parts: a small fragment (S) encoding the nucleocapsid protein (N), a medium size fragment (M) encoding two envelope glycoproteins (G_1, G_2) and Large fragment encoding polymerase associated with virion (L). This article reports two possible HFRS recombinant vaccinia virus vaccines that may be used in humans. The vaccinia virus was originally constructed by the authors for ease of selection