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观察胆囊结石患者血清结合型胆汁酸变化情况 ,探讨结合胆汁酸在临床诊断中的应用。采用反相高效液相色谱法 ,对胆囊结石、结石性胆囊炎和胆总管结石患者血清中六种结合胆汁酸进行测定。三种类型胆囊结石病人血清结合胆汁酸普遍高于对照组。胆囊结石组和结石性胆囊炎组除牛磺胆酸比对照组降低外 ,甘氨胆酸、甘氨脱氧胆酸显著升高。胆总管结石组虽各组分变化不明显 ,但各组分之和仍高于对照组。血清结合胆汁酸各组分在诊断胆囊结石 ,了解和预测结石形成中具有重要作用。
Observe the changes of serum bound bile acid in patients with gallstone and explore the clinical application of combined bile acid. Using reversed-phase high performance liquid chromatography, the determination of six kinds of conjugated bile acids in the serum of patients with gallstone, cholecystolithiasis and choledocholithiasis was performed. Three types of patients with gallstone stones serum bile acid is generally higher than the control group. Gallstone group and calculous cholecystitis group, in addition to taurocholic acid than the control group decreased, glycocholic acid, glycodeoxycholic acid was significantly increased. Although the components of common bile duct stones did not change significantly, but the sum of the components is still higher than the control group. Serum combined with bile acid components in the diagnosis of gallstones, to understand and predict the formation of stones has an important role.