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目的探讨国产吉西他滨联合化放疗治疗晚期非小细胞肺癌(NSCLC)疗效及毒副反应。方法29例患者均为不能手术切除的Ⅲ~Ⅳ期非小细胞肺癌,采用国产吉西他滨全身化疗联合应用直线加速器外照射放疗。结果CR3例、PR15例、SD8例、PD3例,总有效率(CR+PR)62.1%,化放疗后CYFRA21-1有明显下降,与治疗前相比P<0.01,有显著差异,化放疗不良反应较轻。结论国产吉西他滨联合化放疗是治疗不能手术切除的中晚期非小细胞肺癌的有效方法之一。
Objective To investigate the efficacy and side effects of domestic gemcitabine combined with radiotherapy in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Twenty-nine patients with unresectable stage Ⅲ-Ⅳ non-small cell lung cancer were treated with domestic gemcitabine plus systemic radiotherapy combined with external beam radiotherapy. Results The CR3, PR15, SD8 and PD3 cases had a total effective rate (CR + PR) of 62.1%. The CYFRA21-1 level after chemotherapy was significantly lower than that before treatment, P <0.01, there was a significant difference between the two groups The reaction is lighter. Conclusion Domestic gemcitabine combined with radiotherapy is an effective method for the treatment of unresectable advanced non-small cell lung cancer.