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目的:观察肝素钠和多硫酸软骨素是否具有免疫原性。方法:分别用肝素钠、含硫酸软骨素杂质肝素钠和多硫酸软骨素与福氏佐剂混匀免疫家兔,采用酶联免疫吸附试验(ELISA)和琼脂免疫扩散试验检测家兔血清中的抗体。结果:ELISA法未检测到血清中的抗体;琼脂免疫扩散试验血清72h扩散观察未出现沉淀线,没有形成抗原抗体复合物。结论:肝素钠和多硫酸软骨素对家兔无免疫原性。
Objective: To observe whether heparin sodium and chondroitin sulphate are immunogenic. Methods: Rabbits were immunized with heparin sodium, chondroitin sulphate impurity heparin and chondroitin sulphate and Freund’s adjuvant respectively. Serum samples were detected by enzyme-linked immunosorbent assay (ELISA) and agar immunodiffusion assay antibody. Results: Serum antibodies were not detected by ELISA. Serum 72 hours after agar immunodiffusion test showed no precipitation line and no antigen-antibody complex. Conclusion: Heparin sodium and chondroitin sulphate are not immunogenic for rabbits.