Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome

来源 :World Journal of Gastroenterology | 被引量 : 0次 | 上传用户:hongqiulongxi
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
AIM:To investigate the pathophysiology of irritable bowel syndrome(IBS)by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.METHODS:Fifteen IBS patients fulfilling the Rome Ⅱcriteria,and nine healthy volunteers were included in the study.A combined lipidomics(UPLC/MS)and metabolomics(GC×GC-TOF)approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.RESULTS:Overall,lipid levels were elevated in patients with IBS.The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines.Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides,glycosphingolipids,and di-and triacylglycerols.Among the metabolites,the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects(P=0.03).CONCLUSION:IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile.Especially,there was an increase in several lipid species such as lysophospholipids and ceramides. To investigate the pathophysiology of irritable bowel syndrome (IBS) by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls. METHODS: Fifteen IBS patients fulfilling the Rome II condition, and nine healthy volunteers were included in the study. A combined lipidomics (UPLC / MS) and metabolomics (GC × GC-TOF) approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon. RESULTS: Overall, lipid levels were elevated in patients with IBS. The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines. Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides, glycosphingolipids, and di-and triacylglycerols. Amm the metabolites, the cyclic ester 2 (3H) -furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects (P = 0.03) .CONCLUSION: IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile. Especially, there was an increase in several lipid species such as lysophospholipids and ceramides.
其他文献
在学校里,教师们常可以看到同班或同级甚至不同年级的一些学生在课余喜欢三个一群,五个一伙地地在一起谈心、娱乐.运动等,这些兴趣相投、关系相容的学生个集体,通常被称为非
近年来,中核建中核燃料元件有限公司(以下简称中核建中)认真领会十八大报告、习近平总书记关于社会主义核心价值观的系列论述,把弘扬长征精神和培育社会主义核心价值观有机融合起来,凝心聚力,为实现建成国际一流核燃料元件制造基地的目标提供了强大的精神动力。  弘扬长征精神  促进企业中心任务完成  在艰苦创业中弘扬长征精神  20世纪60年代中期,为发展祖国核工业,为建设“三线”大后方,中核建中的老一辈创业
目的用CT灌注成像(CTperfusion,CTP)来探讨蛛网膜下腔出血(subarachnoid hemorrhage,SAH)后脑微循环的改变及其与临床表现、脑血管痉挛(cerebral vasospasm,CVS)的关系。方法
目的:观察蛋白酶体抑制剂Lactacystin诱导大鼠黑质小胶质细胞的变化及炎性介质的表达。方法:采用立体定向术将不同剂量(2μg,10μg)的蛋白酶体抑制剂Lactacystin注射至大鼠黑
国内的大城市,一般早晚上下班时间,街头都会出现川流不息的自行车行列,其中不难看到有的自行车前或后绑着一把小椅子,上面坐着的便是被送往幼儿园的小宝贝。这样的风景线在
花园里有一朵玫瑰,每当有人走到跟前,它就会羞答答地把头低下,如果有人蹲下来想和它说句话,它就更害羞了。只恨身上没有长腿,不然它就会一溜烟地跑掉了。在美丽的校园里,也有
郊外,靠近公路、铁路立交桥,有一块几亩大的草坪。草坪上,置有造型为大象、小羊、小鹿、水牛等动物形象的雕塑,很美丽。地势不一的草坪和由小石子筑起的蜿蜒小路,吸引了众多
86式步兵战车是一种供装甲步兵进行机动和作战的履带式装甲战斗车辆,它具有整体布局合理、机动性好、武器威力大、防护能力强、操纵和保养简便等特点,是我军装甲机械化部队
与学生谈话交往,是班主任工作的一个重要方面.通过谈话,不但能够深入了解学生,掌握学生的思想动态,探究学生发展的过程和规律,从而有效地搞好班级管理工作,而且还能增进师生
错别字是语文教学中历来存在的一个问题。要防止和减少学生阅读和写作中的错别字,必须研究他们经常出现的错别字类型,找出原因,采取相应的教学措施。本文试图对这个问题作一