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目的探讨外阴阴道念珠菌病(VVC)的临床特征和抗真菌药物敏感性。方法对900例VVC患者采用Soble分类对临床特征进行评分,培养、分离菌株,并对不同菌株进行酮康唑、伊曲康唑、氟康唑、两性霉素B体外药敏试验。结果单纯型VVC的临床特征平均分显著低于非白念珠菌VVC和RVVC(P<0.05);689例(76.56%)为白念珠菌,211例(23.44%)为非白念珠菌,两性霉素B的敏感性均为100%,白念珠菌对四种药物的敏感性间有显著性差异(χ2=9.57,P<0.01),非白念珠菌对四种药物的敏感性间有显著性差异(χ2=9.21,P<0.01)。结论白念珠菌是VVC的主要致病菌,念珠菌对唑类药物敏感性有所差异,非白念珠菌的药物敏感性较白念珠菌低,白念珠菌的耐药性不常见。
Objective To investigate the clinical features and antifungal susceptibility of vulvovaginal candidiasis (VVC). Methods The clinical features of 900 VVC patients were scored by Soble classification, and the strains were isolated and cultured. The susceptibility tests of ketoconazole, itraconazole, fluconazole and amphotericin B to different strains were performed. Results The mean clinical score of VVC was significantly lower than that of non-C. albicans VVC and RVVC (P <0.05), 689 (76.56%) were Candida albicans, 211 (23.44%) were Candida albicans, The sensitivities of the two antibiotics were 100%, Candida albicans sensitivity to the four drugs were significantly different (χ2 = 9.57, P <0.01), non-Candida albicans sensitivity to the four drugs were significant Difference (χ2 = 9.21, P <0.01). Conclusion Candida albicans is the main pathogen of VVC. Candida sensitivity to azole is different. The drug sensitivity of non-Candida albicans is lower than that of Candida albicans, but Candida albicans is not common.